LOST
1848 to Zachary Taylor

He was the nominee of the Democratic Party for president in 1848.

Cass represented the State of Michigan in the United States Senate from 1845 to 1848. In 1848 he resigned from the Senate to run for president. Cass was a leading supporter of the Doctrine of Popular Sovereignty, which held that the people who lived in a territory should decide whether or not to permit slavery there. His nomination caused a split in the Democratic party, leading many antislavery Democrats to join the Free Soil Party.

After losing the election to Zachary Taylor, he returned to the Senate, serving from 1849 to 1857.
From 1857 to 1860 Cass served as Secretary of State under President James Buchanan. He resigned on December 13, 1860, reportedly disgusted by Buchanan's failure to pursue a stronger policy that might have averted the threatened secession of southern states.

In December 1860 he retired from the cabinet when the president refused to take a firmer attitude against secession by reinforcing Fort Sumter, and he remained in retirement until his death at Detroit, Michigan, on the 17th of June 1866. 

Remains: Buried, Elmwood Cemetery, Detroit, MI